While this portable version of Defender was originally made for Windows 7 and 8.1, it can still be used to scan for malware on some Windows 10 PCs, depending on the version.
While Windows 10 allows you to conduct an offline virus scan using Microsoft Defender without any additional tools or hardware, you can also use the older Windows Defender Offline tool on a portable USB drive or DVD to conduct a boot-level scan when Windows can’t (or shouldn’t) boot. Using the Older Windows Defender Offline Tool to Scan for Malware (Older Versions of Windows)